Researchers Determine How Mosquitoes Survive Dengue Virus Infection

February 13, 2009 at 2:00 pm Leave a comment


Colorado State University researchers have discovered that mosquitoes that transmit deadly viruses such as dengue avoid becoming ill by mounting an
immediate, potent immune response. Because their immune system does not eliminate the virus, however, they are able to pass it on to a new victim. In
a study published February 13 in the open-access journal PLoS Pathogens, the researchers show that RNA interference – the mosquito immune response
— is initiated immediately after they ingest blood containing dengue virus, but the virus multiplies in the mosquitoes nevertheless.



Dengue fever and dengue hemorrhagic fever are major global public health burdens, with up to 100 million cases occurring annually, yet no vaccines or
specific preventative medicines are currently available. The Aedes aegypti mosquito transmits dengue virus. Determining how the virus evades the
mosquito’s defense is an important next step in research that aims to fight disease by interrupting the growth of dengue virus within the mosquito
before it can be transmitted.





RNA interference is an evolutionarily ancient antiviral defense used by mosquitoes and other invertebrates to destroy the RNA of many invading
arthropod-borne viruses. This team of researchers previously showed that ramping up the RNA interference response in mosquitoes prevented dengue
infection, and now they show that temporarily impairing this immune response increased virus transmission.



The investigators analyzed RNA from adult mosquitoes, finding that both the trigger and initiator molecules for RNA interference were formed after
infection, yet viral RNA could readily be detected in the same mosquitoes. They also measured infectious virus rates in the mosquitoes’ saliva,
which revealed levels whereby the mosquitoes could transmit the disease to humans.



These findings indicate that genetic manipulation of RNA interference could be a significant weapon in stopping dengue virus transmission by Aedes
aegypti.



CITATION:

“Dengue Virus Type 2 Infections of Aedes aegypti
Are Modulated by the Mosquito’s RNA Interference Pathway.”

PLoS Pathog 5(2): e1000299. doi:10.1371/journal.ppat.1000299

http://dx.plos.org/10.1371/journal.ppat.1000299




About PLoS Pathogens



PLoS Pathogens publishes outstanding original articles that significantly advance the understanding of pathogens and how they
interact with their host organisms. All works published in PLoS Pathogens are open access. Everything is immediately available subject only to the
condition that the original authorship and source are properly attributed. Copyright is retained by the authors. The Public Library of Science uses
the Creative Commons Attribution License.



http://www.plospathogens.org



About the Public Library of Science



The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world’s scientific and medical
literature a freely available public resource.



Public Library of Science

[Via http://www.medicalnewstoday.com]

Advertisements

Entry filed under: Uncategorized.

Durability Of Dental Fillings Improves If The Enzyme Activity Of Teeth Is Inhibited Pelvic Lymph Node Dissection (Extended Vs Standard) And Prostate Cancer

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Trackback this post  |  Subscribe to the comments via RSS Feed


Archives

Top Clicks

  • None

Blog Stats

  • 15,568 hits

%d bloggers like this: