Consumption Of A High-fat Meal Increases Production Of RONS Or “free Radicals” In Young, Obese Women

February 5, 2009 at 11:00 am Leave a comment

A new study published in a recent issue of the journal Oxidative Medicine & Cellular Longevity, now links diets with high fat content to the release of excess free radicals in the body. Elevated free radical release in the body, also known as oxidative stress, is sometimes targeted by antioxidants and has been tied to a number of disorders such as heart disease, diabetes and Alzheimer’s disease. The study, which was confined to women, also demonstrated that women who were obese were more likely to have higher and prolonged release of free radicals in the body when compared to non-obese counterparts. These findings shed significant new light on the almost immediate role diet can play in relation to the development of long-term disorders in the body and provides new information to design new therapies for a number of diseases caused by oxidative stress.

Multiple stressors, including but not limited to cigarette smoke exposure, physical work, and consumption of saturated fat and simple sugar containing foods can lead to the production of free radicals. Obese individuals have elevated resting biomarkers of oxidative stress compared to those of normal weight, and have been shown to experience exaggerated oxidative stress in response to physical exercise. This study was designed to determine if obese women are more prone to feeding-induced oxidative stress, as compared to women of normal weight. It was found that the overall oxidative stress in response to a high-fat meal is greater in obese women.

Richard J. Bloomer and Kelsey H. Fisher-Wellman of The University of Memphis authored the report. Bloomer holds a PhD in Exercise Physiology and is an Assistant Professor within the department of Health and Sport Sciences at The University of Memphis, where he directs the Cardiorespiratory/Metabolic Laboratory. His research is focused on oxidative stress and nutraceutical therapy to improve human health and performance.

Kelsey H. Fisher-Wellman received his undergraduate degree in Exercise and Sport Science from The University of Memphis and currently works as a graduate research assistant in Richard Bloomer’s Cardiorespiratory/Metabolic Laboratory conducting research related to the role of both feeding and exercise in inducing an oxidative stress response in humans.

Oxidative Medicine & Cellular Longevity is a new peer-reviewed research journal published by Landes Bioscience that focuses on the cellular and molecular mechanisms of oxidative stress and cell longevity in organ systems of the body and to translate this work for treatment strategies in relation to disorders that may involve aging, cancer, immune function, vascular disease, metabolism, and neurodegeneration. The journal fills a significant void in today’s scientific literature and serves as an international forum for the scientific community worldwide to translate pioneering “Bench to bedside” research into clinical strategies.

Dr. Kenneth Maiese, Editor-in-Chief of Oxidative Medicine & Cellular Longevity, is a physician-scientist whose interests focus on the basic and clinical mechanisms that control neuronal and vascular longevity and immune system function. He presently is the Director of the Division of Cellular and Molecular Cerebral Ischemia and is a Professor in the Departments of Neurology and Anatomy & Cell Biology, the Center for Molecular Medicine and Genetics, the Barbara Ann Karmanos Cancer Institute and the National Institute of Environmental Health Sciences at Wayne State University School of Medicine. His investigations are designed to translate basic science into successful therapeutic treatments for conditions such as cancer, metabolic disorders, cardiovascular disease, diabetes, stroke and Alzheimer’s disease.



Brett Aycock

Managing Editor


Oxidative Medicine & Cellular Longevity


Landes Bioscience

1002 West Avenue, 2nd floor

Austin, Texas 78701

Landes Bioscience



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